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Lab Publications

NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis

Paul, S., Sarraf, S.A., Nam, K.H., Zavar, L., DeFoor, N., Biswas, S.R., Fritsch, L.E., Yaron, T.M., Johnson, J.L., Huntsman, E.M., Cantley, L.C.,

Ordureau, A., Pickrell, A.M. Journal of Cell Biology 2023 Dec 7;223 (2): e202303082.

The Imbalance of Astrocytic Mitochondrial Dynamics Following Blast-Induced Traumatic Brain Injury.

Guilhaume-Correa, F., Pickrell, A.M., VandeVord, P.J. Biomolecules 2023 Jan 24;11(2):329. doi: 10.3390/biomedicines11020329.

Remdesivir increases mtDNA copy number causing mild alterations to oxidative phosphorylation.

DeFoor, N., Paul, S., Li, S., Gudenschwager B, E.K., Stevenson, V., Browning, J.L., Prater, A.K., Brindley, S., Tao, G., and Pickrell, A.M. Scientific Reports 2023 Sep 15;13(1):15339. doi: 10.1038/s41598-023-42704-y.

The role of STING signaling in central nervous system infection and neuroinflammatory disease. 

Fritsch, L. E.,  Kelly, C., &  Pickrell, A. M. (2023). WIREs Mechanisms of Disease 2023 Jan 12; e1597.

Monocyte pro-inflammatory phenotypic control by Ephrin type-A receptor 4 mediates neural tissue damage

Kowalski, E.J.A., Soliman, E., Kelly, C., Basso, E., Leonard, J., Pridham, K.J., Ju, J., Cash, A., Hazy, A., Jager, C., Kaloss, A., Ding, H., Hernandez, R., Coleman, G., Wang, X., Olsen, M.E., Pickrell, A.M., Theus, M.H.

JCI Insight 2022 Jun 23;e156319. doi:10.1172/jci.insight.156319.  Online ahead of print

Type I Interferon Response Is Mediated by NLRX1-cGAS-STING Signaling in Brain Injury

Fritsch LE, Ju J, Gudenschwager Basso EK, Soliman E, Paul S, Chen J, Kaloss AM, Kowalski EA, Tuhy TC, Somaiya RD, Wang X, Allen          

IC, Theus MH*, Pickrell AM*

Front Mol Neurosci. 2022 Feb 25;15:852243.

Early Influences of Microbiota on White Matter Development in Germ-Free Piglets

Ahmed S, Travis SD, Díaz-Bahamonde FV, Porter DDL, Henry SN, Mykins J, Ravipati A, Booker A, Ju J, Ding H, Ramesh AK, Pickrell AM, Wang M, LaConte S, Howell BR, Yuan L, Morton PD. Front Cell Neurosci. 2021 Dec 27;15:807170. doi: 10.3389/fncel.2021.807170. PMID: 35027884; PMCID: PMC8751630.

Hidden Phenotypes of PINK1/Parkin KO mice

Paul, S., Pickrell, A.M.* 

Biochimica et Biophysica Acta 2021 Jun;1865(6):129871. doi: 10.1016/j.bbagen.2021.129871.

Selective autophagic clearance of protein aggregates is mediated by the autophagy receptor, TAX1BP1

Sarraf, S.A., Shah, H.V., Kanfer, G., Pickrell, A.M., Ward, M.E., and Youle, R.J. 

Molecular Cell 2020. Dec 3;80(5):779-795.e10. doi: 10.1016/j.molcel.2020.10.041.

Peripheral loss of EphA4 ameliorates TBI-induced neuroinflammation and tissue damage

Kowalski, E.A.*, Chen, J*, Hazy, A., Fritsch, L.E. Basso, E.K.G., Chen, M., Wang, X., Qian, Y., Zhou, M., Byerly, M., Pickrell, A.M., Matson, J.B., Allen, I.C., and Theus, M.H. 

J Neuroinflammation. 2019.  Nov 11;16(1):210. doi: 10.1186/s12974-019-1605-2.

PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis

Sarraf, S.A.#, Sideris, D.P.#, Giagtzoglou, N., Ni, L., Kankel, M.W., Sen, A., Bochicchio, L.E., Huang, CH., Nussenzweig, S.C., Worley, S.H., Morton, P.D., Artavanis-Tsakonas, S., Youle, R.J., and Pickrell, A.M.* 

Cell Reports. 2019. Oct 1;29(1):225-235.e5. doi: 10.1016/j.celrep.2019.08.085.

EGR1 Recruits TET1 to Shape the Brain Methylome during Development and upon Neuronal Activity

Sun, Z., Xu, X., He, J., Murray, A., Sun, M., Wei, X., Wang, X., McCoig, E., Xie, E., Xi, J., Li, L., Zhu, J., Chen, J., Morozov, A., Pickrell, A.M., Theus, M.H. and Xie, H. 

Nature Communications. 2019. Aug 29;10(1):3892. doi: 10.1038/s41467-019-11905-3.

Oxidative metabolism alterations in the emotional brain of anxiety-prone rats

McCoy, C.R., Sabbagh, M.N., Huaman, J.P., Pickrell, A.M., and Clinton, S.M. 

Prog Neuropsychopharmacol Biol Psychiatry. 2019. Dec 20;95:109706. doi: 10.1016/j.pnpbp.2019.109706.

Ubiquitin and Receptor Dependent Mitophagy Pathways and Their Implication in Neurodegeneration

Fritsch, L.E., Sarraf, S.A., Moore, M.E., and Pickrell, A.M.*

J Molecular Biology 2019 Nov 2. pii: S0022-2836(19)30611-4. doi: 10.1016/j.jmb.2019.10.015.

Methods to Detect Mitophagy in Neurons During Disease

Carter, F.E., Moore, M.E., and Pickrell, A.M. * 

 J. Neurosci. Methods. 2019 1;325:108351.

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